Typesetting is basically putting text on cleans, so making that...
...look like this...
The most important and basic principles are:
0. Having the correct settings [+] [-]
1. Choosing fonts [+] [-]
To typeset nicely, you will need well-fitting and goodlooking fonts. Analyze the picture:

It's not shoujo and it's not ecchi stuff either; the art style is oldschool, it's hard, it's almost edged. So put a text box over a bubble and search through your installed fonts.



Now we got a nice font for the usual talk. Now we gotta look for the other kinds of text there are: thoughts/offtexts, screams and, again depending on your group and in this case the manga, sound-effects. Just do the same procedure again to choose fonts. For screams, it is often enough to just bold the normal font or bold+italic it and raise the font-size a bit. For offtexts, you should generally use more soft or neutral fonts (this does not mean Arial!). If there are narrator's boxes, use even more neutral fonts.

2. Putting in text
[+] [-]
3. Centering, shaping, font-size
[+] [-]
4. Strokes on Offtexts
[+] [-]
5. Rotating texts
[+] [-]
More advanced stuff below:
Warping and rotating texts [+] [-]